Effects of lithium ion on inhibitory GTP-binding proteins
نویسندگان
چکیده
منابع مشابه
Small GTP-binding proteins.
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families. They regulate a wide variety of cell functions as biological timers (biotimers) that initiate and terminate specific cell functions...
متن کاملThe Rheb family of GTP-binding proteins.
Rheb proteins represent a novel and unique family of the Ras superfamily GTP-binding proteins that is conserved from yeast to human. Biochemical studies establish that they bind and hydrolyze GTP. Molecular modeling studies reveal a few structural differences between Rheb and Ras, which may suggest that residues involved in biochemical activities differ between the two G-proteins. The function ...
متن کاملThe ras superfamily of GTP-binding proteins: guidelines on nomenclature.
Over the past several years, a large superfamily of monomeric GTP-binding proteins structurally related to the ras oncogene proteins has been described (1-4). The number of members of this superfamily identified has increased dramatically in recent years, and the number of descriptive terms or names used to denote these proteins has increased almost as dramatically as well. During the recent FA...
متن کاملRegulation of phospholipase C delta 1 activity by GTP-binding proteins: rhoA as an inhibitory modulator.
Phosphatidylinositol4,5-bisphosphate is hydrolysed by phospholipase C (PLC) to form inositol 1,4,5-trisphosphate and diacylglycerol. Each of these products acts as a second messenger in a variety of cellular responses including contraction and cell proliferation [ 1,2]. The PLC family of enzymes consists of three isoforms (P,y,S) which are differentially regulated and expressed. PLCP has been d...
متن کاملSmall gtp-binding proteins in insulin secretion
Glucose-stimulated insulin secretion [GSIS] involves interplay between small G-proteins and their regulatory factors. Herein, we tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide-exchange factor [GEF] for the small G-protein Arf6, mediates the functional activation of Arf6, and that ARNO/Arf6 signaling axis, in turn, controls the activation of Cdc42 and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55176-9